PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis

Liver fibrosis is a pathological scarring response to chronic hepatocellular injury and hepatic stellate cells (HSCs) are key players in this process. PNPLA3 I148M is a common variant robustly associated with liver fibrosis but the mechanisms underlying this association are unknown. We aimed to exam...

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Publié dans:Hum Mol Genet
Auteurs principaux: Pingitore, Piero, Dongiovanni, Paola, Motta, Benedetta Maria, Meroni, Marica, Lepore, Saverio Massimo, Mancina, Rosellina Margherita, Pelusi, Serena, Russo, Cristina, Caddeo, Andrea, Rossi, Giorgio, Montalcini, Tiziana, Pujia, Arturo, Wiklund, Olov, Valenti, Luca, Romeo, Stefano
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886043/
https://ncbi.nlm.nih.gov/pubmed/27742777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw341
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