A simulation study investigating power estimates in phenome-wide association studies

BACKGROUND: Phenome-wide association studies (PheWAS) are a high-throughput approach to evaluate comprehensive associations between genetic variants and a wide range of phenotypic measures. PheWAS has varying sample sizes for quantitative traits, and variable numbers of cases and controls for binary...

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Bibliographic Details
Published in:BMC Bioinformatics
Main Authors: Verma, Anurag, Bradford, Yuki, Dudek, Scott, Lucas, Anastasia M., Verma, Shefali S., Pendergrass, Sarah A., Ritchie, Marylyn D.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885318/
https://ncbi.nlm.nih.gov/pubmed/29618318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2135-0
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