Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis: A Randomized Clinical Trial

IMPORTANCE: Myelofibrosis is a hematologic malignancy characterized by splenomegaly and debilitating symptoms. Thrombocytopenia is a poor prognostic feature and limits use of Janus kinase 1 (JAK1)/Janus kinase 2 (JAK2) inhibitor ruxolitinib. OBJECTIVE: To compare the efficacy and safety of JAK2 inhi...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Mascarenhas, John, Hoffman, Ronald, Talpaz, Moshe, Gerds, Aaron T., Stein, Brady, Gupta, Vikas, Szoke, Anita, Drummond, Mark, Pristupa, Alexander, Granston, Tanya, Daly, Robert, Al-Fayoumi, Suliman, Callahan, Jennifer A., Singer, Jack W., Gotlib, Jason, Jamieson, Catriona, Harrison, Claire, Mesa, Ruben, Verstovsek, Srdan
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885169/
https://ncbi.nlm.nih.gov/pubmed/29522138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.5818
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