Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening

Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular monomeric heme-containing enzyme that catalyzes the first and the rate limiting step in catabolism of tryptophan via the kynurenine (KYN) pathway, which plays a significant role in the proliferation and differentiation of T cells. IDO1 has bee...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Front Pharmacol
Huvudupphovsmän: Zhang, Guoqing, Xing, Jing, Wang, Yulan, Wang, Lihao, Ye, Yan, Lu, Dong, Zhao, Jihui, Luo, Xiaomin, Zheng, Mingyue, Yan, Shiying
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884943/
https://ncbi.nlm.nih.gov/pubmed/29651242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00277
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk