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A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad
One group of enzymes that confer resistance to aminoglycoside antibiotics through covalent modification belongs to the GCN5-related N-acetyltransferase (GNAT) superfamily. We show how a unique GNAT subfamily member uses a previously unidentified noncanonical catalytic triad, consisting of a glutamic...
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| Pubblicato in: | Sci Adv |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Association for the Advancement of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5884680/ https://ncbi.nlm.nih.gov/pubmed/29632894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aas8667 |
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