Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice

Primary liver cancer is the 3rd leading cause of cancer deaths worldwide with very few effective treatments. Sphingosine kinase 1 (SphK1), a key regulator of sphingolipid metabolites, is over-expressed in human hepatocellular carcinoma (HCC) and our previous studies have shown that SphK1 is importan...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Chen, Jinbiao, Qi, Yanfei, Zhao, Yang, Kaczorowski, Dominik, Couttas, Timothy A., Coleman, Paul R., Don, Anthony S., Bertolino, Patrick, Gamble, Jennifer R., Vadas, Mathew A., Xia, Pu, McCaughan, Geoffrey W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884653/
https://ncbi.nlm.nih.gov/pubmed/29643998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24583
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