Membrane permeabilizing amphiphilic peptide delivers recombinant transcription factor and CRISPR-Cas9/Cpf1 ribonucleoproteins in hard-to-modify cells

Delivery of recombinant proteins to therapeutic cells is limited by a lack of efficient methods. This hinders the use of transcription factors or Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) ribonucleoproteins to develop cell therapies. Here, we report a soluble peptide designe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Del’Guidice, Thomas, Lepetit-Stoffaes, Jean-Pascal, Bordeleau, Louis-Jean, Roberge, Joannie, Théberge, Vanessa, Lauvaux, Coraline, Barbeau, Xavier, Trottier, Jessica, Dave, Vibhuti, Roy, Denis-Claude, Gaillet, Bruno, Garnier, Alain, Guay, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884575/
https://ncbi.nlm.nih.gov/pubmed/29617431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195558
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