In Vivo 6-([(18)F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity

BACKGROUND: Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA) is an HDA...

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Dettagli Bibliografici
Pubblicato in:Contrast Media Mol Imaging
Autori principali: Fukumitsu, Nobuyoshi, Yeh, Skye Hsin-Hsien, Flores II, Leo Garcia, Mukhopadhyay, Uday, Young, Daniel, Ogawa, Kazuma, Jeong, Hwan-Jeong, Tong, William, Gelovani, Juri G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884410/
https://ncbi.nlm.nih.gov/pubmed/29755299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/3612027
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