Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer

PURPOSE: The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervous system. However, given that the BTB has increased passive permeability we hypothesize that liposomal irinotecan would improve local exposure of irinotecan and its active metabolite SN-38 in brain m...

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Bibliographic Details
Published in:Pharm Res
Main Authors: Mohammad, Afroz S., Griffith, Jessica I., Adkins, Chris E., Shah, Neal, Sechrest, Emily, Dolan, Emma L., Terrell-Hall, Tori B., Hendriks, Bart S., Lee, Helen, Lockman, Paul R.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884086/
https://ncbi.nlm.nih.gov/pubmed/29368289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2278-0
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