Simvastatin Treatment Upregulates HO-1 in Patients with Abdominal Aortic Aneurysm but Independently of Nrf2

Heme oxygenase-1 (HO-1), encoded by HMOX1 gene and regulated by Nrf2 transcription factor, is a cytoprotective enzyme. Its deficiency may exacerbate abdominal aortic aneurysm (AAA) development, which is also often associated with hyperlipidemia. Beneficial effects of statins, the broadly used antili...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Piechota-Polanczyk, Aleksandra, Kopacz, Aleksandra, Kloska, Damian, Zagrapan, Branislav, Neumayer, Christoph, Grochot-Przeczek, Anna, Huk, Ihor, Brostjan, Christine, Dulak, Jozef, Jozkowicz, Alicja
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883937/
https://ncbi.nlm.nih.gov/pubmed/29743974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/2028936
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