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New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum
BACKGROUND: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. METHODS: A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screen...
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| Pubblicato in: | Malar J |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5883364/ https://ncbi.nlm.nih.gov/pubmed/29615130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-018-2281-x |
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