New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

BACKGROUND: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. METHODS: A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screen...

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Veröffentlicht in:Malar J
Hauptverfasser: Lobo, Lis, Cabral, Lília I. L., Sena, Maria Inês, Guerreiro, Bruno, Rodrigues, António Sebastião, de Andrade-Neto, Valter Ferreira, Cristiano, Maria L. S., Nogueira, Fatima
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883364/
https://ncbi.nlm.nih.gov/pubmed/29615130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-018-2281-x
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