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Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

The antimalarial trioxanes, exemplified by the naturally occurring sesquiterpene lactone artemisinin and its semi-synthetic derivatives, contain an endoperoxide pharmacophore that lends tremendous potency against Plasmodium parasites. Despite decades of research, their mechanism of action remains un...

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Detalhes bibliográficos
Main Authors: Hartwig, Carmony L., Rosenthal, Andrew S., Angelo, John D', Griffin, Carol E., Posner, Gary H., Cooper, Roland A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659783/
https://ncbi.nlm.nih.gov/pubmed/19022224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.10.015
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