Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper understanding of the consequences of this oncogenic mutation. One aspect of the neomorphic function of the IDH1 R132H enzyme that has received less a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Hollinshead, Kate E.R., Munford, Haydn, Eales, Katherine L., Bardella, Chiara, Li, Chunjie, Escribano-Gonzalez, Cristina, Thakker, Alpesh, Nonnenmacher, Yannic, Kluckova, Katarina, Jeeves, Mark, Murren, Robert, Cuozzo, Federica, Ye, Dan, Laurenti, Giulio, Zhu, Wei, Hiller, Karsten, Hodson, David J., Hua, Wei, Tomlinson, Ian P., Ludwig, Christian, Mao, Ying, Tennant, Daniel A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883319/
https://ncbi.nlm.nih.gov/pubmed/29562167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.084
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia