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Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells

Apart from the relevant lipid-lowering effects, statins have demonstrated significant, although heterogeneous, anti-tumor activities in preventing breast cancer (BC) progression. To characterize the critical pathways behind the diverse responses to therapy, we investigated statin-induced changes in...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Lettiero, Barbara, Inasu, Maria, Kimbung, Siker, Borgquist, Signe
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882899/
https://ncbi.nlm.nih.gov/pubmed/29615666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23726-3
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