Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension

Background: Hypertension is characterized by sympathetic overactivity, which is associated with an enhancement in angiotensin receptor type I (AT1R) in the rostral ventrolateral medulla (RVLM). β-arrestin1, a canonical scaffold protein, has been suggested to show a negative effect on G protein-coupl...

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Опубликовано в: :Front Physiol
Главные авторы: Sun, Jia-Cen, Liu, Bing, Zhang, Ru-Wen, Jiao, Pei-Lei, Tan, Xing, Wang, Yang-Kai, Wang, Wei-Zhong
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Physiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882868/
https://ncbi.nlm.nih.gov/pubmed/29643817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00297
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