The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing

The S100A2 protein is an important regulator of keratinocyte differentiation, but its role in wound healing remains unknown. We establish epithelial-specific S100A2 transgenic (TG) mice and study its role in wound repair using punch biopsy wounding assays. In line with the observed increase in proli...

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Udgivet i:Sci Rep
Main Authors: Pan, Shin-Chen, Li, Che-Yu, Kuo, Chia-Yi, Kuo, Yi-Zih, Fang, Wei-Yu, Huang, Yu-Hsuan, Hsieh, Tzu-Chin, Kao, Hung-Ying, Kuo, Yuan, Kang, Ya-Rong, Tsai, Wan-Chi, Tsai, Sen-Tien, Wu, Li-Wha
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882638/
https://ncbi.nlm.nih.gov/pubmed/29615682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23697-5
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