Metformin-induced reduction of CD39 and CD73 blocks myeloid-derived suppressor cell activity in patients with ovarian cancer

Metformin is a broadly prescribed drug for type 2 diabetes that exerts antitumor activity, yet the mechanisms underlying this activity remain unclear. We show here that metformin treatment blocks the suppressive function of myeloid-derived suppressor cells (MDSC) in patients with ovarian cancer (OC)...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Li, Lifeng, Wang, Liping, Li, Jieyao, Fan, Zhirui, Yang, Li, Zhang, Zhen, Zhang, Chaoqi, Yue, Dongli, Qin, Guohui, Zhang, Tengfei, Li, Feng, Chen, Xinfeng, Ping, Yu, Wang, Dan, Gao, Qun, He, Qianyi, Huang, Lan, Li, Hong, Huang, Jianmin, Zhao, Xuan, Xue, Wenhua, Sun, Zhi, Lu, Jingli, Yu, Jane J., Zhao, Jie, Zhang, Bin, Zhang, Yi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882589/
https://ncbi.nlm.nih.gov/pubmed/29374065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2460
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