Anti-estrogen therapy increases plasticity and cancer stemness of prolactin-induced ERα+ mammary carcinomas

Although anti-estrogen therapies are successful in many patients with estrogen receptor alpha-positive (ERα+) breast cancer, 25-40% fail to respond. Although multiple mechanisms underlie evasion of these treatments, including tumor heterogeneity and drug-resistant cancer stem cells (CSCs), further i...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Shea, Michael P., O’Leary, Kathleen A., Fakhraldeen, Saja A., Goffin, Vincent, Friedl, Andreas, Wisinski, Kari B., Alexander, Caroline M., Schuler, Linda A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882549/
https://ncbi.nlm.nih.gov/pubmed/29363543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0985
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