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Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration

G-protein coupled receptor (GPCR) heterodimerization has emerged as a means by which alternative signaling entities can be created; yet, how receptor heterodimers affect receptor pharmacology remains unknown. Previous observations suggested a biochemical antagonism between GPCRs, CXCR4 and CB2 (CNR2...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Scarlett, Kisha A., White, El-Shaddai Z., Coke, Christopher J., Carter, Jada R., Bryant, Latoya K., Hinton, Cimona V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882517/
https://ncbi.nlm.nih.gov/pubmed/29330286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0481
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