Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

BACKGROUND: In a phase 1 trial, axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, showed efficacy in patients with refractory large B-cell lymphoma after the failure of conventional therapy. METHODS: In this multicenter, phase 2 trial, we enro...

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Publicado en:N Engl J Med
Autores principales: Neelapu, S.S., Locke, F.L., Bartlett, N.L., Lekakis, L.J., Miklos, D.B., Jacobson, C.A., Braunschweig, I., Oluwole, O.O., Siddiqi, T., Lin, Y., Timmerman, J.M., Stiff, P.J., Friedberg, J.W., Flinn, I.W., Goy, A., Hill, B.T., Smith, M.R., Deol, A., Farooq, U., McSweeney, P., Munoz, J., Avivi, I., Castro, J.E., Westin, J.R., Chavez, J.C., Ghobadi, A., Komanduri, K.V., Levy, R., Jacobsen, E.D., Witzig, T.E., Reagan, P., Bot, A., Rossi, J., Navale, L., Jiang, Y., Aycock, J., Elias, M., Chang, D., Wiezorek, J., Go, W.Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882485/
https://ncbi.nlm.nih.gov/pubmed/29226797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1707447
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