Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells

Infection with Helicobacter pylori is known to decrease the level of glutathione in gastric epithelial cells and increase the production of reactive oxygen species (ROS), which can lead to DNA damage and the development of gastric cancer. Cation transport regulator 1 (CHAC1) has γ‐glutamylcyclotrans...

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Publicat a:FEBS Open Bio
Autors principals: Wada, Yuriko, Takemura, Kosuke, Tummala, Padmaja, Uchida, Keisuke, Kitagaki, Keisuke, Furukawa, Asuka, Ishige, Yuuki, Ito, Takashi, Hara, Yukichi, Suzuki, Takashige, Mimuro, Hitomi, Board, Philip G., Eishi, Yoshinobu
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881537/
https://ncbi.nlm.nih.gov/pubmed/29632819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12402
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