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Helicobacter pylori induces somatic mutations in TP53 via overexpression of CHAC1 in infected gastric epithelial cells

Infection with Helicobacter pylori is known to decrease the level of glutathione in gastric epithelial cells and increase the production of reactive oxygen species (ROS), which can lead to DNA damage and the development of gastric cancer. Cation transport regulator 1 (CHAC1) has γ‐glutamylcyclotrans...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Wada, Yuriko, Takemura, Kosuke, Tummala, Padmaja, Uchida, Keisuke, Kitagaki, Keisuke, Furukawa, Asuka, Ishige, Yuuki, Ito, Takashi, Hara, Yukichi, Suzuki, Takashige, Mimuro, Hitomi, Board, Philip G., Eishi, Yoshinobu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881537/
https://ncbi.nlm.nih.gov/pubmed/29632819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12402
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