Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ

Precise control of mesenchymal stem cell (MSC) differentiation is critical for tissue development and regeneration. We show here that kindlin-2 is a key determinant of MSC fate decision. Depletion of kindlin-2 in MSCs is sufficient to induce adipogenesis and inhibit osteogenesis in vitro and in vivo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Biol
Prif Awduron: Guo, Ling, Cai, Ting, Chen, Keng, Wang, Rong, Wang, Jiaxin, Cui, Chunhong, Yuan, Jifan, Zhang, Kuo, Liu, Zhongzhen, Deng, Yi, Xiao, Guozhi, Wu, Chuanyue
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881491/
https://ncbi.nlm.nih.gov/pubmed/29496737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612177
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