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PccD Regulates Branched-Chain Amino Acid Degradation and Exerts a Negative Effect on Erythromycin Production in Saccharopolyspora erythraea
Branched-chain amino acid (BCAA) degradation is a major source of propionyl coenzyme A (propionyl-CoA), a key precursor of erythromycin biosynthesis in Saccharopolyspora erythraea. In this study, we found that the bkd operon, responsible for BCAA degradation, was regulated directly by PccD, a transc...
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| Pubblicato in: | Appl Environ Microbiol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881055/ https://ncbi.nlm.nih.gov/pubmed/29439982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00049-18 |
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