Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast

Rapamycin inhibits TOR (target of rapamycin) kinase, and is being used clinically to treat various diseases ranging from cancers to fibrodysplasia ossificans progressiva. To understand rapamycin mechanisms of action more comprehensively, 1014 temperature-sensitive (ts) fission yeast (Schizosaccharom...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Sajiki, Kenichi, Tahara, Yuria, Villar-Briones, Alejandro, Pluskal, Tomáš, Teruya, Takayuki, Mori, Ayaka, Hatanaka, Mitsuko, Ebe, Masahiro, Nakamura, Takahiro, Aoki, Keita, Nakaseko, Yukinobu, Yanagida, Mitsuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881033/
https://ncbi.nlm.nih.gov/pubmed/29593117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.170261
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