Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast

Rapamycin inhibits TOR (target of rapamycin) kinase, and is being used clinically to treat various diseases ranging from cancers to fibrodysplasia ossificans progressiva. To understand rapamycin mechanisms of action more comprehensively, 1014 temperature-sensitive (ts) fission yeast (Schizosaccharom...

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Main Authors: Kenichi Sajiki, Yuria Tahara, Alejandro Villar-Briones, Tomáš Pluskal, Takayuki Teruya, Ayaka Mori, Mitsuko Hatanaka, Masahiro Ebe, Takahiro Nakamura, Keita Aoki, Yukinobu Nakaseko, Mitsuhiro Yanagida
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2018-03-01
Colecção:Open Biology
Assuntos:
rapamycin
sapk
fission yeast
mutant screening
quantitative metabolomics
Acesso em linha:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170261
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