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How Diverse Are the Protein-Bound Conformations of Small-Molecule Drugs and Cofactors?

Knowledge of the bioactive conformations of small molecules or the ability to predict them with theoretical methods is of key importance to the design of bioactive compounds such as drugs, agrochemicals, and cosmetics. Using an elaborate cheminformatics pipeline, which also evaluates the support of...

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Publicat a:Front Chem
Autors principals: Friedrich, Nils-Ole, Simsir, Méliné, Kirchmair, Johannes
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880911/
https://ncbi.nlm.nih.gov/pubmed/29637066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00068
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