Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset

Anaphase onset is an irreversible cell cycle transition that is triggered by the activation of the protease Separase. Separase cleaves the Mcd1 (also known as Scc1) subunit of Cohesin, a complex of proteins that physically links sister chromatids, triggering sister chromatid separation. Separase is...

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Библиографические подробности
Опубликовано в: :PLoS Genet
Главные авторы: Lianga, Noel, Doré, Carole, Kennedy, Erin K., Yeh, Elaine, Williams, Elizabeth C., Fortinez, Camille Marie, Wang, Alick, Bloom, Kerry S., Rudner, Adam D.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880407/
https://ncbi.nlm.nih.gov/pubmed/29561844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007029
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