Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset

Anaphase onset is an irreversible cell cycle transition that is triggered by the activation of the protease Separase. Separase cleaves the Mcd1 (also known as Scc1) subunit of Cohesin, a complex of proteins that physically links sister chromatids, triggering sister chromatid separation. Separase is...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Lianga, Noel, Doré, Carole, Kennedy, Erin K., Yeh, Elaine, Williams, Elizabeth C., Fortinez, Camille Marie, Wang, Alick, Bloom, Kerry S., Rudner, Adam D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880407/
https://ncbi.nlm.nih.gov/pubmed/29561844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007029
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