Identification of novel MECOM gene fusion and personalized therapeutic targets through integrative clinical sequencing in secondary acute myeloid leukemia in a patient with severe congenital neutropenia: a case report and literature review

Severe congenital neutropenia (SCN) is a rare hematologic disorder characterized by defective myelopoiesis and a high incidence of malignant transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). SCN patients who develop MDS/AML have excessive toxicities to traditional ch...

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Bibliografske podrobnosti
izdano v:Cold Spring Harb Mol Case Stud
Main Authors: Connelly, James A., Mody, Rajen J., Wu, Yi-Mi, Robinson, Dan R., Lonigro, Robert J., Vats, Pankaj, Rabban, Erica, Anderson, Bailey, Walkovich, Kelly
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2018
Teme:
Research Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880254/
https://ncbi.nlm.nih.gov/pubmed/29572239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a002204
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