Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog

Mechanistic details of intramembrane aspartyl protease (IAP) chemistry, which is central to many biological and pathogenic processes, remain largely obscure. Here, we investigated the in vitro kinetics of a microbial intramembrane aspartyl protease (mIAP) fortuitously acting on the renin substrate a...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Naing, Swe-Htet, Kalyoncu, Sibel, Smalley, David M., Kim, Hyojung, Tao, Xingjian, George, Josh B., Jonke, Alex P., Oliver, Ryan C., Urban, Volker S., Torres, Matthew P., Lieberman, Raquel L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880133/
https://ncbi.nlm.nih.gov/pubmed/29382721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001436
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