Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells

The BRAF-MKK1/2-ERK1/2 pathway is constitutively activated in response to oncogenic mutations of BRAF in many cancer types, including melanoma. Although small molecules that inhibit oncogenic BRAF and MAP kinase kinase (MKK)1/2 have been successful in clinical settings, resistance invariably develop...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Basken, Joel, Stuart, Scott A., Kavran, Andrew J., Lee, Thomas, Ebmeier, Christopher C., Old, William M., Ahn, Natalie G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880111/
https://ncbi.nlm.nih.gov/pubmed/29255136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000335
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