Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

New therapies are required for melanoma. Here, we report that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to human melanoma cells than normal human cells. This reflects on-target inhibition of the ATP1A1 Na(+)/K(+) pump, which is highly expressed by mel...

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Udgivet i:Nat Commun
Main Authors: Eskiocak, Ugur, Ramesh, Vijayashree, Gill, Jennifer G., Zhao, Zhiyu, Yuan, Stacy W., Wang, Meng, Vandergriff, Travis, Shackleton, Mark, Quintana, Elsa, Johnson, Timothy M., DeBerardinis, Ralph J., Morrison, Sean J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996948/
https://ncbi.nlm.nih.gov/pubmed/27545456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12336
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