Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

New therapies are required for melanoma. Here, we report that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to human melanoma cells than normal human cells. This reflects on-target inhibition of the ATP1A1 Na(+)/K(+) pump, which is highly expressed by mel...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Eskiocak, Ugur, Ramesh, Vijayashree, Gill, Jennifer G., Zhao, Zhiyu, Yuan, Stacy W., Wang, Meng, Vandergriff, Travis, Shackleton, Mark, Quintana, Elsa, Johnson, Timothy M., DeBerardinis, Ralph J., Morrison, Sean J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996948/
https://ncbi.nlm.nih.gov/pubmed/27545456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12336
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados