Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome Dysregulation

Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell cancer exhibiting a wide spectrum of disease courses and treatment responses. Molecular characterization of RNA and DNA from CLL cases has led to the identification of important driver mutations and disease subtypes, but the precise mechan...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Johnston, Harvey E., Carter, Matthew J., Larrayoz, Marta, Clarke, James, Garbis, Spiro D., Oscier, David, Strefford, Jonathan C., Steele, Andrew J., Walewska, Renata, Cragg, Mark S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880099/
https://ncbi.nlm.nih.gov/pubmed/29367434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000539
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