Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome Dysregulation

Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell cancer exhibiting a wide spectrum of disease courses and treatment responses. Molecular characterization of RNA and DNA from CLL cases has led to the identification of important driver mutations and disease subtypes, but the precise mechan...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Johnston, Harvey E., Carter, Matthew J., Larrayoz, Marta, Clarke, James, Garbis, Spiro D., Oscier, David, Strefford, Jonathan C., Steele, Andrew J., Walewska, Renata, Cragg, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880099/
https://ncbi.nlm.nih.gov/pubmed/29367434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000539
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