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Phosphorylation-induced unfolding regulates p19(INK4d) during the human cell cycle
Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). The ankyrin-repeat protein p19(INK4d) functions as a key regulator of G1/S transition; however, its molecular mode of action is unknown. Here, we combine cell and structural biology methods to unravel the mechanism by wh...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5879693/ https://ncbi.nlm.nih.gov/pubmed/29531090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719774115 |
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