UBD modifies APOL1-induced kidney disease risk

People of recent African ancestry develop kidney disease at much higher rates than most other groups. Two specific coding variants in the Apolipoprotein-L1 gene APOL1 termed G1 and G2 are the causal drivers of much of this difference in risk, following a recessive pattern of inheritance. However, mo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Jia-Yue, Wang, Minxian, Tian, Lei, Genovese, Giulio, Yan, Paul, Wilson, James G., Thadhani, Ravi, Mottl, Amy K., Appel, Gerald B., Bick, Alexander G., Sampson, Matthew G., Alper, Seth L., Friedman, David J., Pollak, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879665/
https://ncbi.nlm.nih.gov/pubmed/29531077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716113115
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