Cation-Independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate

Palmitate attenuates insulin secretion and reduces the viability of insulin-producing cells. Previous studies identified the aberrant palmitoylation or mispalmitoylation of proteins as one mechanism by which palmitate causes β-cell damage. In this report, we identify a role for lysosomal protein deg...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Baldwin, Aaron C., Naatz, Aaron, Bohnsack, Richard N., Bartosiak, Jacob T., Oleson, Bryndon J., Hansen, Polly A., Dahms, Nancy M., Corbett, John A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879465/
https://ncbi.nlm.nih.gov/pubmed/29378831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00680-17
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