Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population

The currently Food and Drug Administration–approved anticonvulsant for the treatment of status epilepticus (SE) induced by nerve agents is the benzodiazepine diazepam; however, diazepam does not appear to offer neuroprotective benefits. This is of particular concern with respect to the protection of...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Apland, James P., Aroniadou-Anderjaska, Vassiliki, Figueiredo, Taiza H., Pidoplichko, Volodymyr I., Rossetti, Katia, Braga, Maria F. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2018
Témata:
Drug Discovery and Translational Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878669/
https://ncbi.nlm.nih.gov/pubmed/29467308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.245969
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