Shank3‐deficient thalamocortical neurons show HCN channelopathy and alterations in intrinsic electrical properties

KEY POINTS: Shank3 increases the HCN channel surface expression in heterologous expression systems. Shank3 (Δ13–16) deficiency causes significant reduction in HCN2 expression and I (h) current amplitude in thalamocortical (TC) neurons. Shank3 (Δ13–16)‐ but not Shank3 (Δ4–9)‐deficient TC neurons shar...

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Bibliographic Details
Published in:J Physiol
Main Authors: Zhu, Mengye, Idikuda, Vinay Kumar, Wang, Jianbing, Wei, Fusheng, Kumar, Virang, Shah, Nikhil, Waite, Christopher B., Liu, Qinglian, Zhou, Lei
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878232/
https://ncbi.nlm.nih.gov/pubmed/29327340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275147
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