Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Neuronal apoptosis in the hippocampus has been detected after TBI. The hippocampal dysfunction may result in cognitive deficits in learning, memory, and spatial information processing. Our previous studies demonstrated...

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Vydáno v:Neurobiol Dis
Hlavní autoři: Yang, Ling-Yu, Greig, Nigel H., Huang, Ya-Ni, Hsieh, Tsung-Hsun, Tweedie, David, Yu, Qian-Sheng, Hoffer, Barry J., Luo, Yu, Kao, Yu-Chieh, Wang, Jia-Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878046/
https://ncbi.nlm.nih.gov/pubmed/27553877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.08.012
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