Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion

The β-barrel assembly machine (Bam) complex folds and inserts integral membrane proteins into the outer membrane of Gram-negative bacteria. The two essential components of the complex, BamA and BamD, both interact with substrates, but how the two coordinate with each other during assembly is not cle...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Lee, James, Sutterlin, Holly A., Wzorek, Joseph S., Mandler, Michael D., Hagan, Christine L., Grabowicz, Marcin, Tomasek, David, May, Mary D., Hart, Elizabeth M., Silhavy, Thomas J., Kahne, Daniel
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877925/
https://ncbi.nlm.nih.gov/pubmed/29463713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711727115
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