Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics

Drug resistant HIV is a major threat to the long-term efficacy of antiretroviral treatment. Around 10% of ART-naïve patients in Europe are infected with drug-resistant HIV type 1. Hence it is important to understand the dynamics of transmitted drug resistance evolution. Thanks to routinely performed...

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Vydáno v:PLoS Pathog
Hlavní autoři: Kühnert, Denise, Kouyos, Roger, Shirreff, George, Pečerska, Jūlija, Scherrer, Alexandra U., Böni, Jürg, Yerly, Sabine, Klimkait, Thomas, Aubert, Vincent, Günthard, Huldrych F., Stadler, Tanja, Bonhoeffer, Sebastian
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877888/
https://ncbi.nlm.nih.gov/pubmed/29462208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006895
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