2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO

The 5' RNA cap structure ((m7)GpppRNA) is a key feature of eukaryotic mRNAs with important roles in stability, splicing, polyadenylation, mRNA export, and translation. Higher eukaryotes can further modify this minimal cap structure with the addition of a methyl group on the ribose 2'-O pos...

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Udgivet i:PLoS One
Main Authors: Picard-Jean, Frédéric, Brand, Carolin, Tremblay-Létourneau, Maude, Allaire, Andréa, Beaudoin, Maxime C., Boudreault, Simon, Duval, Cyntia, Rainville-Sirois, Julien, Robert, Francis, Pelletier, Jerry, Geiss, Brian J., Bisaillon, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877831/
https://ncbi.nlm.nih.gov/pubmed/29601584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193804
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