Transgenic rescue implicates β(2)-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice

Type 1 diabetes in both humans and nonobese diabetic (NOD) mice results from T-cell-mediated autoimmune destruction of insulin-producing pancreatic β cells. Linkage studies have shown that type 1 diabetes in NOD mice is a polygenic disease involving more than 15 chromosomal susceptibility regions. D...

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Autori principali: Hamilton-Williams, Emma E., Serreze, David V., Charlton, Brett, Johnson, Ellis A., Marron, Michele P., Müllbacher, Arno, Slattery, Robyn M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC58764/
https://ncbi.nlm.nih.gov/pubmed/11572996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191383798
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