Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses

The tumor microenvironment (TME) is composed by cellular and non-cellular components. Examples include the following: (i) bone marrow-derived inflammatory cells, (ii) fibroblasts, (iii) blood vessels, (iv) immune cells, and (v) extracellular matrix components. In most cases, this combination of comp...

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Udgivet i:Front Oncol
Main Authors: Morrot, Alexandre, da Fonseca, Leonardo Marques, Salustiano, Eduardo J., Gentile, Luciana Boffoni, Conde, Luciana, Filardy, Alessandra Almeida, Franklim, Tatiany Nunes, da Costa, Kelli Monteiro, Freire-de-Lima, Celio Geraldo, Freire-de-Lima, Leonardo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876249/
https://ncbi.nlm.nih.gov/pubmed/29629338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00081
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