High Levels of DEK Autoantibodies in Sera of Patients With Polyarticular Juvenile Idiopathic Arthritis and With Early Disease Flares Following Cessation of Anti–Tumor Necrosis Factor Therapy

OBJECTIVE: The nuclear oncoprotein DEK is an autoantigen associated with juvenile idiopathic arthritis (JIA), especially the oligoarticular subtype. DEK is a secreted chemotactic factor. Abundant levels of DEK and DEK autoantibodies are found in inflamed synovium in JIA. We undertook this study to f...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Mor‐Vaknin, Nirit, Rivas, Miguel, Legendre, Maureen, Mohan, Smriti, Yuanfan, Ye, Mau, Theresa, Johnson, Anne, Huang, Bin, Zhao, Lili, Kimura, Yukiko, Spalding, Steven J., Morris, Paula W., Gottlieb, Beth S., Onel, Karen, Olson, Judyann C., Edelheit, Barbara S., Shishov, Michael, Jung, Lawrence K., Cassidy, Elaine A., Prahalad, Sampath, Passo, Murray H., Beukelman, Timothy, Mehta, Jay, Giannini, Edward H., Adams, Barbara S., Lovell, Daniel J., Markovitz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Pediatric Rheumatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876119/
https://ncbi.nlm.nih.gov/pubmed/29287303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40404
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