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Nanoparticles Decorated with Viral Antigens are More Immunogenic at Low Surface Density

There is an urgent need to develop protective vaccines for high priority viral pathogens. One approach known to enhance immune responses to viral proteins is to display them on a nanoparticle (NP) scaffold. However, little is known about the effect of protein density on the B cell response to antige...

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Dettagli Bibliografici
Pubblicato in:Vaccine
Autori principali: Brewer, Matthew G, DiPiazza, Anthony, Acklin, Joshua, Feng, Changyong, Sant, Andrea J., Dewhurst, Stephen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876043/
https://ncbi.nlm.nih.gov/pubmed/28057386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.12.049
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