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Nanoparticles Decorated with Viral Antigens are More Immunogenic at Low Surface Density

There is an urgent need to develop protective vaccines for high priority viral pathogens. One approach known to enhance immune responses to viral proteins is to display them on a nanoparticle (NP) scaffold. However, little is known about the effect of protein density on the B cell response to antige...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Brewer, Matthew G, DiPiazza, Anthony, Acklin, Joshua, Feng, Changyong, Sant, Andrea J., Dewhurst, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876043/
https://ncbi.nlm.nih.gov/pubmed/28057386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.12.049
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