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A Mitosis-Specific and R Loop-Driven ATR Pathway Promotes Faithful Chromosome Segregation
The ATR kinase is crucial for DNA damage and replication stress responses. Here we describe a surprising role of ATR in mitosis. Acute inhibition or degradation of ATR in mitosis induces whole-chromosome missegregation. The effect of ATR ablation is not due to altered CDK1 activity, DNA damage respo...
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| Опубликовано в: : | Science |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5875943/ https://ncbi.nlm.nih.gov/pubmed/29170278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan6490 |
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